Uterine Atony

Overview

Uterine atony — the failure of the uterus to contract after delivery — is a leading cause of postpartum hemorrhage worldwide. Despite its clinical significance, the molecular mechanisms underlying atony remain poorly understood.

Approach

Using Python, I analyzed proteomic and RNA-seq data from 21 patients with healthy and atonic uterine muscle. The analysis identifies proteins and genes that differ between the two groups, maps them onto biological pathways to find disrupted processes, and groups patients by molecular severity.

Methods

The pipeline combines differential expression analysis with pathway enrichment to move beyond individual gene hits and identify systems-level dysfunction. Patient clustering reveals molecular subtypes that may respond differently to treatment.

Significance

By identifying the specific molecular pathways disrupted in atonic uterine muscle, this work aims to reveal new targets for preventing or treating postpartum hemorrhage.